Heterogeneity in ventilation during positive end-expiratory pressure

geneity in ventilation be good’ [1] and the related article by Zhao and colleagues [2]. We agree with the comments that instead of incremental positive end-expiratory pressure (PEEP) levels, a decremented PEEP titration might be an attractive option for determining optimal PEEP [1,3]. However, we feel that physiological inhomogeneity in ventilation and perfusion related to the gravitational eff ect in normal lungs occurs during spontaneous breathing, and during spontaneous breathing a negative alveolar pressure develops during inspiration and facilitates pulmonary blood fl ow. Contrary to when applying PEEP, the positive pressure remains throughout respira tion and paradoxically aff ects the pulmonary fl ow. We feel that it would be wiser not to compare the physiological inhomogeneity in ventilation with PEEPrelated inhomo genous ventilation. PEEP is a slow recruitment technique for aerating collapsed alveoli, which can happen in a non-uniform fashion. Hence, anticipating any good eff ect of inhomogeneity of ventilation during PEEP may give a false impression to physicians regarding mechanically ventilated patients in the ICU. Respiratory parameters such as lung mechanics and arterial blood gas refl ect global ventilation. Th e readily available bedside chest X-ray is useful to map the inhomogeneity of the alveolar recruitment during PEEP in acute respiratory distress syndrome patients. Th e lung infi ltration score for the diff erent lung zones can map heterogeneity in lung recruitment [4]. Th is heterogeneity between the two lungs (lung infi ltration score diff erence ≥3) was associated with postural hypoxemia when the worst lung was down in the lateral position and predisposed to skin sores on the worst lung side [4]. We opine that lung changes comprise a dynamic process in the ICU. Any PEEP level that is appropriate at one point of time may be required to be reevaluated at a later time or, for that matter, even after chest physiotherapy. Understandably, there cannot be a single ideal PEEP level that satisfi es all clinical objectives and situations.